Oxidative Stress Profile

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Oxidative stress is an imbalance between free radicals and antioxidants in the body, leading to damage to organs and tissues, potentially resulting in various diseases.

Vibrant Oxidative stress is a comprehensive and advanced test that measures 16 oxidative damage markers to your DNA, RNA, protein, Lipids and 32 genetic variants to personalize your genetic disposition to Antioxidant enzymes.

What's Included:
Resources:
All of our laboratory tests are performed in an CLIA-certified facility in California.
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Why Test for Oxidative Stress

Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and the body’s antioxidant defenses, which can't effectively neutralize these reactive compounds. Excessive oxidation can actively harm critical cellular components such as lipids, DNA, RNA, and proteins, which are the building blocks of the human body.

WhyCircle

Improving Your Oxidative Damage Score is Key to

Longevity

Oxidative stress can accelerate aging processes. Knowing your Oxidative damage score and making lifestyle changes to improve your score is important for increased HealthSpan.

Key Markers

Gene

  • PRKAA2
  • CAT
  • COX-2
  • CYB5R3
  • CYP1A1
  • GLUL
  • GPX1
  • GPX2
  • GPX4
  • GPX1
  • GSTM1
  • GSTM5
  • GSTP1
  • GSS
  • GSR
  • HMOX1
  • CYBA
  • SELENOP
  • SOD1
  • SOD2
  • SOD3
  • TXNRD1
  • TXNRD2
  • TRXR2
  • XDH

Lipid Peroxidation

  • Malondialdehyde
  • Glutathione 4-hydroxynonenal (GS-HNE)
  • 8-iso-prostaglandin F2α (8-iso-PGF2α)
  • 11-β-Prostaglandin F2α
  • 15(R)-Prostaglandin F2α

Nitrative Stress Biomarkers

  • 8-Nitroguanosine
  • 8-Nitroguanine
  • Nitrotyrosine

DNA Damage

  • 8-Hydroxy-2-deoxyguanosine (8-OHdG)
  • 8-Hydroxyguanine
  • 8-Hydroxyguanosine

Protein Oxidation

  • Dityrosine
  • Bromotyrosine
  • Chlorotyrosine

Advanced glycation products

  • Nε-(caroboxymethyl)lysine (CML)
  • Nε -carboxyethyllysine (CEL)
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What to Expect

  1. Follow our simple instructions to perform this test at home or at a practitioner’s office.
  2. Before testing:
    • Your provider may ask you to discontinue medications or dietary supplements. Speak with your provider to learn more.
  3. Send the test to our labs for analysis and work with your care provider to understand the results.

Why is this Important

  • The Oxidative Stress Profile measures 32 common SNPs and 16 markers of oxidative damage to assess your genetic ability to manage oxidative stress, as well as your current stress status.
  • Oxidative stress poses a threat to longevity as it is implicated in the development of various diseases.
  • This state of stress can create a detrimental cycle where one condition exacerbates another, leading to further health complications.
  • By understanding your oxidative stress, your provider can tailor treatment strategies to address potential weaknesses in the oxidative stress system, reduce buildup of ROS, and promote better health and longevity.
  • With this comprehensive profile, you can better understand your ability to manage oxidative stress and specific antioxidant needs and create personalized wellness plans tailored to your genetics.
Oxidative Stress Mobile Report-1

Additional Resources

Sample Report

Collection Instructions

Complete Markers List

Key Clinical Messages

Patient One-Pager

Publications & Research

Vibrant Advantage

Vibrant’ s Oxidative Stress Profile measures more analytes than any other test on the market, WITH Utilizing state-of-the-art Mass Spectrometer technology, we ensure the gold standard in measurement accuracy for all oxidative damage markers.

16 markers measuring oxidative damage across DNA, RNA, lipids, and proteins

Assesses 32 genetic variants in the antioxidant reduction pathway

Oxidative Damage Score reveals aging rate based on DNA, lipid, and protein damage compared to chronological age

Personalized treatment plans that support body's own antioxidants

Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

Why Test Total Tox Along with Oxidative Stress Profile?

Oxidative Stress

Why it Matters

Combining the Oxidative Stress Profile with the Total Tox Burden offers an in-depth snapshot of how genetics and toxic exposure may accelerate oxidative damage.

Key Insights

The Oxidative Stress Profile offers a comprehensive evaluation of oxidative stress by assessing a broad range of markers that indicate damage caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) to lipids, DNA, RNA, and proteins. This detailed assessment provides valuable insights into the extent of oxidative damage, enabling tailored interventions for patients to mitigate oxidative stress-related health risks.

What’s Measured

  16 Genes  and    32 Damage product

Total Tox Burden

Why it Matters

Environmental exposure to toxins, heavy metals, pollutants, and industrial chemicals can trigger oxidative stress by catalyzing ROS production, promoting free radical production, depleting antioxidants, and inhibiting their protective functions.

Key Insights

The Total Tox Burden assesses the total toxic burden in the body by measuring mycotoxin, heavy metal, and environmental chemical excretion in the urine. This bundle includes three different tests to assess the overall impact of toxic exposure, measuring mycotoxins, heavy metals, and environmental chemical markers.

What’s Measured
  • 20 heavy metals
  • 29 mycotoxins
  • 39 environmental toxins

How It Works

Process1
Order Your Test

Your wellness provider orders your lab test

Process2
Activate Your Kit

Scan the QR CODE to activate your kit.

Process3

Collect Your Sample

Follow the instructions included in your test kit to collect your sample.

Process4

Ship Immediately

Ship your sample to our lab team for analysis.

Process5

Receive Personalized Results

Receive your personalized report within 2-3 weeks.

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Regulatory Statement

Vibrant testing does not demonstrate absolute positive and negative predictive values for any disease state or condition. Its clinical utility has not been fully established.Vibrant validates the accuracy and precision of the testing but not of its clinical or diagnostic value. So these tests are for wellness and informational purpose only. Vibrant is actively doing clinical research on these samples, de-identified from patients under an IRB and will make research publications towards the same as and when the clinical utility is well established.These tests have been laboratory developed and their performance characteristics determined by Vibrant America LLC, a CLIA-certified laboratory performing the test CLIA#:05D2078809. The test has not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests.The general wellness test intended uses relate to sustaining or offering general improvement to functions associated with a general state of health while making reference to diseases or conditions. Content provided for informational purposes only and should not be construed as medical advice. Content provided to help you make healthy lifestyle, dietary, and treatment choices in consultation with your healthcare provider. It is intended to be used as a tool to encourage a general state of health and well-being. Please consult with your healthcare practitioner for diagnosis and treatment considerations.

This test is not available in NY.